Key word: nanocalcium, bone mineral metabolism, preventing bone loss
Effects of nanocalcium supplemented milk on bone mineral metabolism in ovariectomized rats
Department of Food Science and Technology, Sejong University
H. S. Park, B. J. Jeon, N. C. Kim, K. H. Seon and H. S. Kwak
This study was conducted to investigate the effects of calcium supplementation in milk on bone loss in ovariectomized rats. Thirty Sprague-Dawley rats of 8 week-old were divided into 4 groups, overiectomized, and fed the diet and 1 mL milk containing: 1) OVX1, the commercial milk by intubation, 2) OVX2, the calcium carbonate supplemented milk, 3) OVX3, ionized calcium supplemented milk, and 4) OVX4, nanocalcium supplemented milk. After 18 wk feeding, body weight gain and food intake efficiency ratio were not significantly different among groups except for food intake efficiency ratio between OVX4 and OVX1 (p > 0.05). The weights of femur and tibia were not significantly different among all groups. There was no difference in dry weight and ash weight, however, calcium or phosphorus contents in dry weight or ash weight were significantly higher in OVX4. In addition, femoral BMD (bone mineral density) appeared to be greater in OVX4, which supplemented with nanocalcium than those in other groups (p < 0.05). Among groups, OVX4 group showed the highest bone strength as stiffness (p < 0.05) and sightly higher in maximum energy compared with other groups. Trabecular bone areas (%) in tibia were significantly higher in OVX4 group (p < 0.05). The present study indicated that nanocalcium supplementation in milk among other kinds of calcium supplementartion showed the higher contents of calcium and phosphorus in femur and tibia, and the greater stiffness compared with other kinds of calcium supplementation. Therefore, nanocalcium supplementation might have a potential role for preventing bone loss and enhancing bone sparing effects in ovariectomized rats.
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